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- Title
Overview of cancer incidence and mortality among people living with HIV/AIDS in British Columbia, Canada: Implications for HAART use and NADM development.
- Authors
Chiu, Connie G.; Smith, Danielle; Salters, Kate A.; Wendy Zhang; Kanters, Steve; Milan, David; Montaner, Julio S. G.; Coldman, Andy; Hogg, Robert S.; Wiseman, Sam M.; Zhang, Wendy
- Abstract
<bold>Background: </bold>The objective of this study is to evaluate the incidence of non-AIDS defining malignancies (NADMs) among people living with HIV/AIDS (PLWHA) in British Columbia, focusing on clinical correlates, highly active antiretroviral therapy (HAART) use, and survival, in order to elucidate mechanisms for NADM development.<bold>Methods: </bold>A retrospective population based analysis was carried out for individuals with HIV/AIDS that began their treatment between 1996 and 2008.<bold>Results: </bold>There were 145 (2.95%) NADMs and 123 (2.50%) AIDS defining malignancies (ADMs) identified in 4918 PLWHA in the study population. NADMs were represented by a range of cancer types including, most commonly, lung cancer, followed by anal, breast, head/neck, prostate, liver, rectal, and renal cancers. PLWHA had a SIR of 2.05 (CI:1.73, 2.41) for the development of NADMs compared to individuals without an HIV/AIDS diagnosis in the general population. Independent factors significantly associated with a NADM were: male gender, older age, lower CD4 cell counts, previous NADM, absence of HAART (non-HAART versus HAART) and treatment during the early-HAART era (before 2000 versus after 2000).<bold>Conclusions: </bold>NADMs represent an important source of morbidity for PLWHA. Use of HAART with its associated improvement in immune-restoration, and tailored targeted cancer screening interventions, may be beneficial and improve outcomes in this unique patient population.
- Subjects
BRITISH Columbia; HIV-positive persons; DISEASE incidence; HIGHLY active antiretroviral therapy; RENAL cancer; HEAD &; neck cancer diagnosis; COMBINATION drug therapy; RECTAL cancer diagnosis; DRUG therapy for AIDS; AIDS epidemiology; MORTALITY of AIDS patients; HIV infection epidemiology; AGE distribution; AIDS; HIV infections; SEX distribution; TUMORS; RETROSPECTIVE studies; ANTI-HIV agents
- Publication
BMC Cancer, 2017, Vol 17, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-017-3229-1