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- Title
Neutral effect of Glioma-associated oncogene-1 expression on survival in myelofibrosis.
- Authors
Lucijanic, Marko; Livun, Ana; Tupek, Katarina Marija; Stoos-Veic, Tajana; Pejsa, Vlatko; Jonjic, Zeljko; Dzankic, Amina Fazlic; Ivic, Marija; Kusec, Rajko
- Abstract
Summary: This study retrospectively analyzed glioma-associated oncogene 1 (GLI‑1) mRNA expression in unfractionated bone marrow aspirates of 32 patients with myelofibrosis and 16 controls. It was found that GLI‑1 expression did not significantly differ between primary, secondary myelofibrosis and controls (median difference in threshold cycles ∆CT 7.2, 7.3 and 6.9, respectively; P = 0.864), as well as that survival curves of myelofibrosis patients with higher/lower GLI‑1 expression showed multiple overlaps and overall comparable course (P = 0.651). The results suggest that general upregulation of GLI‑1 does not seem to be a feature of the disease and are in line with modest biological and clinical effects observed with inhibitors of Hedgehog signaling pathway in patients with myelofibrosis.
- Subjects
MYELOFIBROSIS; BONE marrow; PHILADELPHIA chromosome
- Publication
Wiener Klinische Wochenschrift, 2020, Vol 132, Issue 15/16, p464
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-019-01572-1