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- Title
Sensitivity to artemisinin, mefloquine and quinine of Plasmodium falciparum in northwestern Thailand.
- Authors
Hüttinger, Felix; Satimai, Wichai; Wernsdorfer, Gunther; Wiedermann, Ursula; Congpuong, Kanungnit; Wernsdorfer, Walther H.
- Abstract
The increasing drug resistance of Plasmodium falciparum is a worldwide problem. The objective of the study was the assessment of the in vitro activity of artemisinin, mefloquine and quinine, in an area where P. falciparum is multi-drug resistant. The sensitivity tests were based on measuring the drug-dependent inhibition of schizont maturation. For the 43 successfully tested isolates the mean effective concentrations (IC and IC) for artemisinin were 0.0081 and 0.1372 μM, respectively. For mefloquine the IC was 0.1260 μM and the IC was 3.7345 μM. Quinine showed an IC of 0.2155 μM and an IC of 2.5040 μM. All tested drugs showed a significant reduction in the effectiveness, compared with the results of former years. This suggests a further rise of resistance of local P. falciparum, which is alarming especially for artemisinin and quinine.
- Publication
Wiener Klinische Wochenschrift, 2010, Vol 122, p52
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-010-1438-6