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- Title
miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b
- Authors
Mizuno, Yosuke; Tokuzawa, Yoshimi; Ninomiya, Yuichi; Yagi, Ken; Yatsuka-Kanesaki, Yukiko; Suda, Tatsuo; Fukuda, Toru; Katagiri, Takenobu; Kondoh, Yasumitsu; Amemiya, Tomoyuki; Tashiro, Hideo; Okazaki, Yasushi
- Abstract
Abstract: Although microRNAs (miRNAs) are involved in many biological processes, the mechanisms whereby miRNAs regulate osteoblastic differentiation are poorly understood. Here, we found that BMP-4-induced osteoblastic differentiation of bone marrow-derived ST2 stromal cells was promoted and repressed after transfection of sense and antisense miR-210, respectively. A reporter assay demonstrated that the activin A receptor type 1B (AcvR1b) gene was a target for miR-210. Furthermore, inhibition of transforming growth factor-β (TGF-β)/activin signaling in ST2 cells with SB431542 promoted osteoblastic differentiation. We conclude that miR-210 acts as a positive regulator of osteoblastic differentiation by inhibiting the TGF-β/activin signaling pathway through inhibition of AcvR1b.
- Subjects
NON-coding RNA; BONE cells; CELL differentiation; ACTIVIN; CELL receptors; BONE marrow; TRANSFORMING growth factors
- Publication
FEBS Letters, 2009, Vol 583, Issue 13, p2263
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.06.006