We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
IFNγ enhances IL-23 production during Francisella infection of human monocytes
- Authors
Butchar, Jonathan P.; Parsa, Kishore V.L.; Marsh, Clay B.; Tridandapani, Susheela
- Abstract
Abstract: We previously demonstrated that monocytes produce IL-23 during Francisella infection, and that IL-23 induces IFNγ from NK cells. Here, we demonstrate that IFNγ-priming of monocytes enhances IL-23 production during Francisella infection. This effect was seen on the IL12/23 p40 subunit. Induction of IL-12/23 p40 is reported to be enhanced by IRF-1 and IRF-8. Consistently, microarray analysis of IFNγ-treated monocytes revealed a significant induction of the IRFs. Interestingly, IFNγ-primed monocytes produced IL-12 p70, a more potent inducer of IFNγ than IL-23. We propose that there exists an amplification loop between monocyte IL-23 and NK/T cell IFNγ that leads to IL-12 p70 production.
- Subjects
FRANCISELLA; MONOCYTES; GRAM-negative bacteria; LEUCOCYTES
- Publication
FEBS Letters, 2008, Vol 582, Issue 7, p1044
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.02.058