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- Title
Inhibition of SH2-domain containing inositol phosphatase 2 (SHIP2) in insulin producing INS1E cells improves insulin signal transduction and induces proliferation
- Authors
Grempler, Rolf; Leicht, Stefanie; Kischel, Ivonne; Eickelmann, Peter; Redemann, Norbert
- Abstract
Abstract: Inhibition of the lipid phosphatase SH2-domain containing inositol phosphatase 2 (SHIP2) in L6-C10 muscle cells, in 3T3-L1 adipocytes and in the liver of db/db mice has been shown to ameliorate insulin signal transduction and established SHIP2 as a negative regulator of insulin action. Here we show that SHIP2 inhibition in INS1E insulinoma cells increased Akt, glycogen synthase kinase 3 and extracellular signal-regulated kinases 1 and 2 phosphorylation. SHIP2 inhibition did not prevent palmitate-induced apoptosis, but increased cell proliferation. Our data raise the interesting possibility that SHIP2 inhibition exerts proliferative effects in β-cells and further support the attractiveness of a specific inhibition of SHIP2 for the treatment of type 2 diabetes.
- Subjects
INSULIN; FAT cells; CELLULAR signal transduction; HYPOGLYCEMIC agents
- Publication
FEBS Letters, 2007, Vol 581, Issue 30, p5885
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.066