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- Title
The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas
- Authors
Tiemessen, Machteld M.; Baert, Miranda R. M.; Schonewille, Tom; Brugman, Martijn H.; Famili, Farbod; Salvatori, Daniela C. F.; Meijerink, Jules P. P.; Ozbek, Ugur; Clevers, Hans; van Dongen, Jacques J. M.; Staal, Frank J. T.
- Abstract
Tcf1 is known to function as a transcriptional activator of Wnt-induced proliferation during T cell development in the thymus. Evidence for an additional contrasting role for Tcf1 as a T-cell specific tumor suppressor gene is now presented.
- Subjects
WNT protein genetics; CELL proliferation; T cells; THYMUS tumors; TUMOR suppressor genes; PHYSIOLOGY
- Publication
PLoS Biology, 2012, Vol 10, Issue 11, p1
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.1001430