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- Title
The N-terminal cleavage of cellular prion protein in the human brain
- Authors
Laffont-Proust, Isabelle; Faucheux, Baptiste A.; Hässig, Raymonde; Sazdovitch, Véronique; Simon, Stéphanie; Grassi, Jacques; Hauw, Jean-Jacques; Moya, Kenneth L.; Haïk, Stéphane
- Abstract
Abstract: Human brain cellular prion protein (PrPc) is cleaved within its highly conserved domain at amino acid 110/111↓112. This cleavage generates a highly stable C-terminal fragment (C1). We examined the relative abundance of holo- and truncated PrPc in human cerebral cortex and we found important inter-individual variations in the proportion of C1. Neither age nor postmortem interval explain the large variability observed in C1 amount. Interestingly, our results show that high levels of C1 are associated with the presence of the active ADAM10 suggesting this zinc metalloprotease as a candidate for the cleavage of PrPc in the human brain.
- Subjects
CEREBRAL cortex; AMINO acids; BRAIN; TELENCEPHALON
- Publication
FEBS Letters, 2005, Vol 579, Issue 28, p6333
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.10.013