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- Title
Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis
- Authors
Ekkelenkamp, Miquel B.; Hanssen, Micha; Danny Hsu, Shang-Te; de Jong, Ad; Milatovic, Dana; Verhoef, Jan; van Nuland, Nico A.J.
- Abstract
Abstract: The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.
- Subjects
ANTIBIOTICS; AMINO acids; NUCLEAR magnetic resonance; PEPTIDES
- Publication
FEBS Letters, 2005, Vol 579, Issue 9, p1917
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.01.083