We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes
- Authors
Mandal, Debabrata; Moitra, Prasun K.; Saha, Samiran; Basu, Joyoti
- Abstract
The appearance of phosphatidylserine (PS) on the outer surface of red cells is an important signal for their uptake by macrophages. We report for the first time that procaspase 3 present in the anucleated mature human erythrocyte is activated under oxidative stress induced by t-butylhydroperoxide leading to impairment of the aminophospholipid translocase, PS externalization and increased erythrophagocytosis. This is the first report linking caspase 3 activation to inhibition of flippase activity and uptake of red cells by macrophages.
- Subjects
PHOSPHATIDYLSERINES; MACROPHAGES
- Publication
FEBS Letters, 2002, Vol 513, Issue 2/3, p184
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02294-9