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- Title
Validation of an extraction paper chromatography (EPC) technique for estimation of trace levels of Sr in Y solutions obtained from Sr/Y generator systems.
- Authors
Pandey, Usha; Kumar, Yogendra; Dash, Ashutosh
- Abstract
While the extraction paper chromatography (EPC) technique constitutes a novel paradigm for the determination of few Becquerels of Sr in MBq quantities of Y obtained from Sr/Y generator, validation of the technique is essential to ensure its usefulness as a real time analytical tool. With a view to explore the relevance and applicability of EPC technique as a real time quality control (QC) technique for the routine estimation of Sr content in generator produced Y, a systematic validation study was carried out diligently not only to establish its worthiness but also to broaden its horizon. The ability of the EPC technique to separate trace amounts of Sr in the presence of large amounts of Y was verified. The specificity of the technique for Y was demonstrated with Y obtained by neutron irradiation. The method was validated under real experimental conditions and compared with a QC method described in US Pharmacopeia for detection of Sr levels in Y radiopharmaceuticals.
- Subjects
EXTRACTION (Chemistry); PAPER chromatography; TRACE elements; STRONTIUM compounds; RADIONUCLIDIC purity; NEUTRON irradiation
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2014, Vol 300, Issue 1, p355
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-014-2981-9