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- Title
Catalytic Enantioselective [4+2] Cycloadditions of Salicylaldehyde Acetals with Enol Ethers.
- Authors
Hu, Xiaojun; Zhu, Zhengbo; Li, Zhongzheng; Adili, Alafate; Odagi, Minami; Abboud, Khalil A.; Seidel, Daniel
- Abstract
A readily accessible conjugate‐base‐stabilized carboxylic acid (CBSCA) catalyst facilitates highly enantioselective [4+2] cycloaddition reactions of salicylaldehyde‐derived acetals and cyclic enol ethers, resulting in the formation of polycyclic chromanes with oxygenation in the 2‐ and 4‐positions. Stereochemically more complex products can be obtained from racemic enol ethers. Spirocyclic products are also accessible.
- Subjects
ENOL ethers; RING formation (Chemistry); ACETAL resins; CYCLIC ethers; CARBOXYLIC acids; BRONSTED acids; OXYGEN in the blood
- Publication
Angewandte Chemie, 2024, Vol 136, Issue 4, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202315759