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- Title
Repeatability of ultrashort echo time-based two-component T<sub>2</sub><sup>*</sup> measurements on cartilages in human knee at 3 T.
- Authors
Qian, Yongxian; Williams, Ashley A.; Chu, Constance R.; Boada, Fernando E.
- Abstract
Repeatability of in vivo measurement of multicomponent T2* relaxation in articular cartialges in human knee is important to clinical use. This study evaluated the repeatability of two-component T2* relaxation on seven healthy human subjects. The left knee was scanned once a day in three consecutive days, on a clinical 3T MRI scanner with eight-channel knee coil and ultrashort echo time pulse sequence at 11 echo times = 0.6-40 ms. The intrasubject and intersubject repeatability was evaluated via coefficient of variation (CV = standard deviation/mean) in four typical cartilage regions: patellar, anterior articular, femoral, and tibial regions. It was found that the intrasubject repeatability was good, with CV < 10% for the short- and long- T2* relaxation time in the layered regions in the four cartilages (with one exception) and CV < 13% for the component intensity fraction (with two exceptions). The intersubject repeatability was also good, with CV ∼8% (range 1-15%) for the short- and long- T2* relaxation time and CV ∼10% (range 2-20%) for the component intensity fraction. The long- T2* component showed significantly better repeatability (CV ∼8%) than the short- T2* component (CV∼12%) ( P < 0.005). These CV values suggest that in vivo measurement of two-component T2* relaxation in the knee cartilages is repeatable on clinical scanner at 3 T, with a signal-to-noise ratio of 90. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
- Publication
Magnetic Resonance in Medicine, 2013, Vol 69, Issue 6, p1564
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.24392