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- Title
Prognosis of patients with advanced gastric cancer by HER2 status and trastuzumab treatment.
- Authors
Shitara, Kohei; Yatabe, Yasushi; Matsuo, Keitaro; Sugano, Masato; Kondo, Chihiro; Takahari, Daisuke; Ura, Takashi; Tajika, Masahiro; Ito, Seiji; Muro, Kei
- Abstract
Background: The purpose of this study was to evaluate the impact of human epidermal growth factor receptor 2 (HER2) status and trastuzumab treatment on the prognosis of patients with advanced gastric cancer (AGC). Methods: We retrospectively analyzed 364 AGC patients who received systemic chemotherapy. To evaluate the impact of trastuzumab exposure during any type of chemotherapy, our analysis used time-varying covariates to avoid a possible lead-time bias. Results: Among the 364 patients, 58 (15.9 %) were HER2-positive. The median overall survival of the HER2-positive patients treated with trastuzumab ( n = 43) was significantly longer than that of the HER2-negative patients [ n = 306; 24.7 vs. 13.9 months, with an adjusted hazard ratio (HR) of 0.58; 95 % confidence interval (CI), 0.36-0.95; P = 0.03]. Notably, 22 patients continued with trastuzumab beyond the date of progression. By contrast, the HER2-positive patients not treated with trastuzumab ( n = 15) showed survival similar to that of the HER2-negative patients (13.5 vs. 13.9 months, with an adjusted HR of 1.04; 95 % CI, 0.52-2.11; P = 0.91). According to the multivariate analysis, exposure to trastuzumab was independently associated with a better prognosis (HR 0.56; 95 % CI; 0.33-0.93; P = 0.026). Conclusions: Recent HER2-positive AGC patients have a better prognosis than HER2-negative patients, particularly when treated with trastuzumab.
- Subjects
GASTRIC mucosa; EPIDERMAL growth factor receptors; TRASTUZUMAB; CANCER chemotherapy; DISEASE progression; MULTIVARIATE analysis; CANCER
- Publication
Gastric Cancer, 2013, Vol 16, Issue 2, p261
- ISSN
1436-3291
- Publication type
Article
- DOI
10.1007/s10120-012-0179-9