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- Title
Bicyclo[3.2.0]carbocyclic Molecules and Redox Biotransformations: The Evolution of Closed-Loop Artificial Linear Biocatalytic Cascades and Related Redox-Neutral Systems.
- Authors
Willetts, Andrew
- Abstract
The role of cofactor recycling in determining the efficiency of artificial biocatalytic cascades has become paramount in recent years. Closed-loop cofactor recycling, which initially emerged in the 1990s, has made a valuable contribution to the development of this aspect of biotechnology. However, the evolution of redox-neutral closed-loop cofactor recycling has a longer history that has been integrally linked to the enzymology of oxy-functionalised bicyclo[3.2.0]carbocyclic molecule metabolism throughout. This review traces that relevant history from the mid-1960s to current times.
- Subjects
BIOCONVERSION; MOLECULES; OXIDATION-reduction reaction; MEMBRANE reactors; ENZYMOLOGY
- Publication
Molecules, 2023, Vol 28, Issue 21, p7249
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28217249