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- Title
Modifications of the homeostasis model assessment of insulin resistance index with age.
- Authors
Soriguer, Federico; Colomo, Natalia; Valdés, Sergio; Goday, Alberto; Rubio-Martín, Elehazara; Esteva, Isabel; Castaño, Luis; Ruiz de Adana, María; Morcillo, Sonsoles; Calle, Alfonso; García-Fuentes, Eduardo; Catalá, Miguel; Gutiérrez-Repiso, Carolina; Delgado, Elias; Gomis, Ramón; Ortega, Emilio; Rojo-Martínez, Gemma
- Abstract
The aim of the study was to analyze the association between aging and insulin resistance estimated by the homeostasis model assessment of insulin resistance (HOMA-IR). This work involved two studies: (1) the Di@bet.es study is a cross-sectional study including 4,948 subjects, comprising a representative sample of the adult Spanish population; (2) the Pizarra study is a population-based cohort study undertaken in Pizarra (Spain), in which 1,051 subjects were evaluated at baseline and 714 completed the 6-year follow-up study. Study variables included a clinical and demographic structured survey, a lifestyle survey, a physical examination, and an oral glucose tolerance test in subjects without diabetes. In the Di@bet.es study overall, an increase occurred in blood glucose until the age of 50, after which it remained stable (data adjusted for gender, body mass index, abnormal glucose regulation [AGR]). The HOMA-IR increased significantly with age ( p = 0.01), due to a higher prevalence of obesity ( p < 0.0001) and AGR ( p < 0.001). In non-obese subjects without AGR, HOMA-IR values were not modified with age ( p = 0.30), but they were with body mass index ( p < 0.001). In the Pizarra study, the HOMA-IR was significantly lower after 6-year follow-up in the whole study population. Subjects with a HOMA-IR level higher than the 75th percentile at baseline were more likely to develop diabetes (OR 2.2, 95 % CI 1.2-3.9; p = 0.007) than subjects with a lower HOMA-IR. We concluded that age per se did not increase HOMA-IR levels, changes that might be related to higher rates of obesity and AGR in older subjects. The HOMA-IR was associated with an increased risk of developing type 2 diabetes 6 years later.
- Subjects
SPAIN; INSULIN resistance; HOMEOSTASIS; AGING -- Immunological aspects; AGE factors in health behavior; TYPE 2 diabetes -- Nutritional aspects; OBESITY -- Nutritional aspects; PUBLIC health
- Publication
Acta Diabetologica, 2014, Vol 51, Issue 6, p917
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-013-0523-5