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- Title
Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows.
- Authors
Kumar, Sudershan; Srivastava, Anil; Dumka, V.; Kumar, Naresh; Raina, Rajinder
- Abstract
Pharmacokinetics and milk levels of ceftriaxone were studied in healthy and endometritic cows following single intravenous administration. The drug was detected up to 8 h of dosing in plasma of healthy and endometritic cows and the drug disposition followed three-compartment open model. The values of Vdarea, AUC, t1/2β, ClB, MRT and P/C ratio were 0.50 ± 0.19 L.kg−1, 62.2 ± 23.3 μg.ml−1.h, 1.02 ± 0.07 h, 0.30 ± 0.09 L.kg−1.h−1, 1.55 ± 0.25 h and 0.52 ± 0.27, respectively, in healthy and 1.55 ± 0.52 L.kg−1, 37.0 ± 17.1 μg.ml−1.h, 1.56 ± 0.25 h, 0.56 ± 0.14 L.kg−1.h−1, 2.14 ± 0.34 h and 1.44 ± 0.60, respectively, in endometritic cows. The drug was detected in milk for 36 h after administration. For MIC90 of 0.5 μg.ml−1 the most appropriate dosage for ceftriaxone, would be 9.0 mg.kg−1 repeated at 6 h intervals for the treatment of endometritis in cows.
- Subjects
PHARMACOKINETICS; COWS; BLOOD plasma; DRUG administration; MEDICAL statistics; ENDOMETRIAL diseases; MILK yield; THERAPEUTICS; ANIMAL health
- Publication
Veterinary Research Communications, 2010, Vol 34, Issue 6, p503
- ISSN
0165-7380
- Publication type
Article
- DOI
10.1007/s11259-010-9421-2