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- Title
Treatment of Ménière's disease with isosorbide.
- Authors
Kitahara, Masaaki; Takeda, Taizo; Yazawa, Yoshiro; Matsubara, Hideharu; Kitano, Hiroya; Kitahara, M; Takeda, T; Yazawa, Y; Matsubara, H; Kitano, H
- Abstract
The effects of isosorbide - a dehydric alcohol formed by the abstraction of two molecules of water from one of sorbitol - on Ménière's disease were examined, first using a model and then clinically. (1) The endolymphatic pressure of guinea pigs with hydrops, caused by the injection of 10% silver nitrate into the endolymphatic sac, could be reduced by the administration of isosorbide. (2) In a clinical study of 102 patients with Ménière's disease, isosorbide significantly reduced tinnitus and headache compared with the control groups. Copyright © 1982 S. Karger AG, Basel
- Subjects
DIURETICS; ANIMAL experimentation; ANIMALS; COCHLEA; GUINEA pigs; MENIERE'S disease; PRESSURE; SORBITOL; ENDOLYMPH; THERAPEUTICS
- Publication
ORL, 1982, Vol 44, Issue 4, p232
- ISSN
0301-1569
- Publication type
journal article
- DOI
10.1159/000275597