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- Title
Listeria monocytogenes internalins bind to the human intestinal mucin MUC2.
- Authors
Lindén, Sara K.; Bierne, Hélène; Sabet, Christophe; Chin Wen Png; Florin, Timothy H.; McGuckin, Michael A.; Cossart, Pascale
- Abstract
Listeria monocytogenes cross the intestinal barrier causing systemic infections with high mortality rates. Intestinal infection triggers release of intestinal mucus. We show that three L. monocytogenes internalins, InlB, InlC and InlJ all bound to MUC2 (the major component of intestinal mucus), but not to the cell surface mucin MUC1. Binding was strongest to InlB>InlC>InlJ ( P < 0.001). Listerial internalins are characterized by their internalin domain, composed by leucine rich repeats (LRR) followed by an immunogloblin-like region. We report here that the internalin domain of the InlJ protein also bound MUC2, suggesting that an internalin domain is sufficient to bind to MUC2.
- Subjects
LISTERIA monocytogenes; LISTERIA; MUCINS; INTESTINAL infections; LEUCINE; IMMUNOGLOBULINS; MORTALITY; CELL membranes; MUCUS
- Publication
Archives of Microbiology, 2008, Vol 190, Issue 1, p101
- ISSN
0302-8933
- Publication type
Article
- DOI
10.1007/s00203-008-0358-6