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- Title
An Overview of Heparin-Induced Thrombocytopenia.
- Authors
Donovan, Jennifer L.; Tran, Maichi T.; Kanaan, Abir O.
- Abstract
Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug reaction to heparin products leading to a prothrombotic state. Devastating clinical sequelae may result, including venous or arterial thromboembolism, limb amputation, and death. Heparin cessation alone is insufficient to manage HIT. Pharmacotherapy with argatroban or lepirudin is essential. This article reviews the pathogenesis, diagnosis, and pharmacotherapy of HIT.
- Subjects
THROMBOCYTOPENIA; HEPARIN; DRUG side effects; THROMBOSIS; THROMBOEMBOLISM treatment; AMPUTATION; PREVENTION; DISEASE risk factors
- Publication
Journal of Pharmacy Practice, 2010, Vol 23, Issue 3, p226
- ISSN
0897-1900
- Publication type
Article
- DOI
10.1177/0897190010362171