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- Title
Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant Disease.
- Authors
Şeber, Selcuk; Güze, Savaş; Yılmaz, Ahsen; Kara, Sonat Pınar; Yetişyiğit, Tarkan
- Abstract
Objective: Serum CA 19.9 is commonly used as a tumor marker for diagnosis and followup of gastrointestinal malignancies. However, elevated levels can be found in various clinical conditions. Methods: A total of 285 patients whose serum CA 19.9 level was ordered from various outpatient clinics other than oncology in a tertiary hospital setting and who had elevated CA 19.9 (>34 U/mL) levels were included in the study group. Statistical analysis of marker levels in relation to diagnosis of patients was performed. Results: Overall, 226 patients with benign disorders and 59 patients with malignant disease had elevated CA 19-9 levels. One hundred ten (39%) patients with increased CA 19-9 levels did not have any significant clinical condition associated with high CA 19-9 values. Median CA 19-9 levels were significantly higher in patients with malignancies than in patients with benign disorders (67.3 vs. 47.9; p<0.001). Receiver operating characteristic curve analysis identified a cut-off value of 66.3 U/mL for discrimination of malignant from benign gastrointestinal diseases (sensitivity 58.3% and specificity 82.7%; p<0.001). Conclusion: Serum CA 19-9 levels are significantly higher in patients with malignant diseases. However, there are diverse etiologies associated with elevated serum levels. During chronic inflammatory states, elevated serum CA 19-9 levels can be a frequent finding.
- Subjects
TUMOR markers; SERUM; CANCER diagnosis; TUMOR antigens
- Publication
Southern Clinics of Istanbul Eurasia, 2019, Vol 30, Issue 3, p198
- ISSN
2587-0998
- Publication type
Article
- DOI
10.14744/scie.2019.82905