We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Klotho 蛋白在糖尿病肾病中的研究进展.
- Authors
王岚; 邹新蓉; 王小琴
- Abstract
Diabetic nephropathy(DN) is one of microvascular complications of diabetes mellitus and is a leading cause of end-stage renal failure.As a kind of complicated disease,various cytokines and signaling pathways have been shown to mediate renal damage in DN.The optimal treatment for DN remains undefined.Seeking for a novel therapeutic target will be important in treatment of DN.Klotho is an anti-aging protein that exerts its biological functions through multiple modes on different kidney diseases.Klotho is closely associated with the pathogenesis of kidney injury in DN.This article will review its renoprotection effects via 4 kinds of potential mechanisms such as anti-vascular calcification,anti-endothelial dysfuction,anti-oxidative stress and anti-fibrosis.
- Publication
Chinese Journal of Clinical Healthcare, 2019, Vol 22, Issue 1, p126
- ISSN
1672-6790
- Publication type
Article
- DOI
10.3969/J.issn.1672-6790.2019.01.033