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- Title
Oxygen in the Setting of Acute Myocardial Infarction: Is It Really a Breath of Fresh Air?
- Authors
Loomba, Rohit S.; Nijhawan, Karan; Aggarwal, Saurabh; Arora, Rohit R.
- Abstract
<bold>Introduction: </bold>Supplemental oxygen has been used in the setting of acute myocardial infarction (AMI). Once an official recommendation in the guidelines for the management of acute ST-segment elevation myocardial infarction, it is now mentioned as an intervention to be considered. Data for the use of supplemental oxygen or AMI are limited, and some data have suggested associated harm.<bold>Methods: </bold>We performed a systematic review of the literature and a subsequent meta-analysis of the data to determine the effect of high concentration oxygen versus titrated oxygen or room air in the setting of AMI. The following end points were studied: in-hospital mortality, opiate use, percentage of infarcted myocardium by magnetic resonance imaging (MRI), and mass of infarcted myocardium by MRI.<bold>Results: </bold>No significant difference was noted with end points when comparing those randomized to high-concentration oxygen versus those randomized to titrated oxygen or room air in the setting of AMI. No significant publication bias was identified although this could not be assessed for all end points.<bold>Conclusion: </bold>High-concentration oxygen may not offer any benefit when compared to titrated oxygen or room air. A large, randomized trial is warranted to further delineate these differences with respect to multiple end points.
- Subjects
MYOCARDIAL infarction-related mortality; HYPEROXIA; CARDIAC magnetic resonance imaging; OXYGEN; MYOCARDIUM physiology; MYOCARDIAL infarction diagnosis; MYOCARDIAL infarction treatment; ELECTROCARDIOGRAPHY; META-analysis; OXYGEN therapy; SYSTEMATIC reviews; HOSPITAL mortality
- Publication
Journal of Cardiovascular Pharmacology & Therapeutics, 2016, Vol 21, Issue 2, p143
- ISSN
1074-2484
- Publication type
journal article
- DOI
10.1177/1074248415598004