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- Title
The Potential of Tissue Flap Transfer Following Inguinal Dissection to Restore Lymphatic Flow in Rats.
- Authors
Kurnia, Ahmad; Kurniawan, Febriyanto; Ramadhan, Ramadhan
- Abstract
Background: The incidence of lymphedema ranges from 9 to 41 percent in breast cancer patients who had axillary dissections. Despite some efforts to prevent lymphedema, such as sentinel lymph node biopsy (SLNB) to overcome axillary dissection, the lymphedema still occurs in 4 - 10% of patients. Prior researches reported positive outcomes of lymphedema treated with tissue flap transfer procedures. Hence, the goal of this study is to investigate the potential association between tissue flap transfer following lymph node dissection and the lymphatic flow in the dissection area. Methods: Identification of inguinal lymphatic flow was done by blue dye injection to Sprague-Dawley rats. Inguinal lymph node dissections were conducted to 32 subjects. The first group, consisted of 16 rats, were only given inguinal dissection without flap. The second group, consisted of 16 rats received inguinal dissection with tissue flap transfer. After two months, the comparison of lymphatic flow on both groups was carried out by identifying any inguinal blue dye flow or the colored lymph node presence. Results: Only 12.5% of subjects that only received inguinal dissections showed lymphatic flows. In contrast, 81.2% of subjects in the group that received inguinal dissections with tissue flap transfers showed lymphatic flows. Tissue flap transfer procedure was significantly associated with restored lymphatic flow (Relative risk [RR] = 6.50, 95%, confidence interval [CI] = 1.74 - 24.27, p < 0.001) Conclusion: The implementation of the tissue flap transfer following lymph node dissection is potential to restore the lymphatic flow.
- Subjects
SURGICAL flaps; LYMPHEDEMA diagnosis; SENTINEL lymph node biopsy; CONFIDENCE intervals; LYMPH node surgery
- Publication
Surgical Chronicles, 2020, Vol 25, Issue 4, p323
- ISSN
1108-5002
- Publication type
Article