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- Title
Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives.
- Authors
Lavalle, Carlo; Trivigno, Sara; Vetta, Giampaolo; Magnocavallo, Michele; Mariani, Marco Valerio; Santini, Luca; Forleo, Giovanni Battista; Grimaldi, Massimo; Badagliacca, Roberto; Lanata, Luigi; Ricci, Renato Pietro
- Abstract
Flecainide is an IC antiarrhythmic drug (AAD) that received in 1984 Food and Drug Administration approval for the treatment of sustained ventricular tachycardia (VT) and subsequently for rhythm control of atrial fibrillation (AF). Currently, flecainide is mainly employed for sinus rhythm maintenance in AF and the treatment of idiopathic ventricular arrhythmias (IVA) in absence of ischaemic and structural heart disease on the basis of CAST data. Recent studies enrolling patients with different structural heart diseases demonstrated good effectiveness and safety profile of flecainide. The purpose of this review is to assess current evidence for appropriate and safe use of flecainide, 30 years after CAST data, in the light of new diagnostic and therapeutic tools in the field of ischaemic and non-ischaemic heart disease.
- Subjects
UNITED States. Food &; Drug Administration; VENTRICULAR arrhythmia; FLECAINIDE; ARRHYTHMIA; VENTRICULAR tachycardia; HEART diseases
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 16, p3696
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10163696