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- Title
Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors.
- Authors
Prill, Monika; Karkucinska-Wieckowska, Agnieszka; Lebiedzinska-Arciszewska, Magdalena; Morciano, Giampaolo; Charzynska, Agata; Dabrowski, Michal; Pronicki, Maciej; Pinton, Paolo; Grajkowska, Wieslawa; Wieckowski, Mariusz R.; Baltuch, Gordon H.
- Abstract
Numerous papers have reported altered expression patterns of Ras and/or ShcA proteins in different types of cancers. Their level can be potentially associated with oncogenic processes. We analyzed samples of pediatric brain tumors reflecting different groups such as choroid plexus tumors, diffuse astrocytic and oligodendroglial tumors, embryonal tumors, ependymal tumors, and other astrocytic tumors as well as tumor malignancy grade, in order to characterize the expression profile of Ras, TrkB, and three isoforms of ShcA, namely, p66Shc, p52Shc, and p46Shc proteins. The main aim of our study was to evaluate the potential correlation between the type of pediatric brain tumors, tumor malignancy grade, and the expression patterns of the investigated proteins.
- Subjects
BRAIN tumors; PROTEIN expression; CHOROID plexus; TUMOR grading
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 10, p2219
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10102219