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- Title
Portal Thrombosis in Cirrhosis: Role of Thrombophilic Disorders.
- Authors
Fortea, José Ignacio; García Carrera, Inés; Puente, Ángela; Cuadrado, Antonio; Huelin, Patricia; Álvarez Tato, Carmen; Álvarez Fernández, Paloma; Pérez Montes, María del Rocío; Nuñez Céspedes, Javier; Batlle López, Ana; González Sanchez, Francisco José; López Hoyos, Marcos; Crespo, Javier; Fábrega, Emilio; Gracia-Sancho, Jordi
- Abstract
In patients with liver cirrhosis the contribution of inherited and acquired prothrombotic disorders in the development of non-malignant portal vein thrombosis (PVT) is inconclusive. The purpose of this retrospective study was to examine the prevalence of thrombophilia in this setting at our center from January 2012 to November 2019. Tests included gene mutational analysis for Factor V Leiden, prothrombin G20210A, JAK2 (V617F), Calreticulin (CARL), in addition to activated protein C resistance, antithrombin III, protein C and S levels, and antiphospholipid antibodies. We included 77 patients, six of whom (7.8%) had a thrombophilic disorder: antiphospholipid syndrome in four patients, prothrombin gene mutation in one and factor V Leiden mutation in one. This latter patient had also been diagnosed with polycythemia vera years before PVT development. Complete thrombosis of the main portal vein and re-thrombosis after stopping anticoagulation were more frequent in patients with thrombophilia, but the rates of recanalization under anticoagulant therapy were similar among groups. No other difference was accounted between groups. The low prevalence of acquired and inherited thrombophilia found in patients with cirrhosis and PVT support testing for these disorders on an individual basis and avoiding universal screening to reduce costs and unwarranted testing.
- Subjects
ACTIVATED protein C resistance; PORTAL vein diseases; THROMBOSIS; GENETIC mutation; ANTITHROMBIN III; PROTEIN C; PHOSPHOLIPID antibodies
- Publication
Journal of Clinical Medicine, 2020, Vol 9, Issue 9, p2822
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm9092822