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- Title
Ginsenosides Enhance the Transduction of Tat-Superoxide Dismutase into Mammalian Cells and Skin.
- Authors
Dae Won Kim; Won Sik Eum; Sang Ho Jang; Chang Sik Yoon; Hee Soon Choi; Soo Hyun Choi; Young Hoon Kim; So Young Kim; Eun Shil Lee; Nam-ln Baek; Hyeok Yil Kwon; Jin Hi Choi; Yoon Chul Choi; Oh-Shin Kwon; Sung-Woo Cho; Kyuhyung Han; Kil Soo Lee; Jinseu Park; Soo Young Choi
- Abstract
We previously reported that Tat-Cu,Zn-superoxide dismutase (Tat-SOD), a major antioxidant enzyme, can be directly transduced into mammalian cells and skin [Kwon et al. (2000); Park et al. (2002)]. To enhance the therapeutic potential of Tat-SOD in the treatment of various disorders, we screened a number of natural products for their ability to increase transduction efficiency. Ginsenosides were effective with cultured HeLa cells and enhanced the penetration of Tat-SOD into both the epidermis and the dermis of the subcutaneous layer when sprayed on mice skin. Although their mechanism of action is not fully understood we believe that ginsenusides may be useful cofactors with this antioxidant enzyme in anti-aging cosmetics or as a therapeutic protein in disorders related to reactive-oxygen species.
- Subjects
SUPEROXIDE dismutase; ANTIOXIDANTS; ENZYMES; CELLS; OXIDOREDUCTASES
- Publication
Molecules & Cells (Springer Nature), 2003, Vol 16, Issue 3, p402
- ISSN
1016-8478
- Publication type
Article
- DOI
10.1016/s1016-8478(23)13819-2