We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The effects of Glucose-Insulin-Potassium Solution and BN 52021 in Intestinal Ischemia-Reperfusion Injury.
- Authors
Aldemir, Mustafa; Gürel, Ahmet; Büyükbayram, Hüseyin; Taçyildiz, Ibrahim
- Abstract
The objective of this study was to investigate effects of glucose-insulin-potassium (GIK) solution and BN 52021, a platelet-activating factor antagonist, on intestinal ischemia-repert:usion injury. Fifty male Sprague-Dawley rats (200-225 g) were divided into 5 groups each containing 10 rats; group SO, sham operation group; group 1, mesenteric ischemia group (for 30 minutes); group R, ischemia plus reperfusion (for 60 minutes); group BR, ischemia-reperfusion plus BN 52021; group GR, ischemia-reperfusion plus GIK solution. Samples for malondialdehyde (MDA) and ileum (for mucosal injury score) were obtained. The mucosal injury scores of group R were significantly higher than those of group I (4 ± 0.20 and 3 ± 0.16, respectively, p<0.0001). The scores of groups BR and GR were significantly lower than those of group R (p<0.0001 and p<0.0001, respectively). When it was compared with the injuries in BR and GR groups, similar results were obtained in both groups (p=0.190). Mean MDA levels of group R were significantly higher than those of group I, BR and GR (131.33 ± 3.99 nmol/g, 93.74 ± 3.22 nmol/g, 104.81 ± 2.56 and 100.34 ± 5.30, respectively, p<0.0001). MDA levels of group BR and GR were significantly lower than those of group I (p < 0.0001 and p=0.003, respectively). These observations suggest that treatment with GIK solution and BN 52021 before reperfusion and during reperfusion period may be useful in decreasing intestinal reperfusion injury.
- Subjects
GLUCOSE; INSULIN; POTASSIUM; ISCHEMIA; REPERFUSION injury
- Publication
Vascular & Endovascular Surgery, 2003, Vol 37, Issue 5, p345
- ISSN
1538-5744
- Publication type
Article
- DOI
10.1177/153857440303700506