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- Title
The Structure of the Hfq Protein from Chromobacterium haemolyticum Revealed a New Variant of Regulation of RNA Binding with the Protein.
- Authors
Lekontseva, N. V.; Nikulin, A. D.
- Abstract
The structure of the Hfq protein from the bacterium Chromobacterium haemolyticum, which forms crystals in two different spatial groups, has been determined. In both cases, the protein has a specific quaternary hexamer-ring structure. The obtained structure showed a previously undescribed interaction between the C-terminal unstructured part of Hfq and the amino acid residues of the proximal RNA-binding site of the protein. This contact may contribute to the regulation of the binding of RNA molecules to the Hfq protein.
- Subjects
RNA-binding proteins; RNA regulation; PROTEIN structure; QUATERNARY structure; AMINO acid residues
- Publication
Crystallography Reports, 2023, Vol 68, Issue 6, p905
- ISSN
1063-7745
- Publication type
Article
- DOI
10.1134/S1063774523600928