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- Title
Neuroprotective effects of LBP on brain ischemic reperfusion neurodegeneration.
- Authors
H.-B. WANG; Y.-X. LI; Y.-J. HAO; T.-F. WANG; Z. LEI; Y. WU; Q.-P. ZHAO; H. WANG; L. MA; J. LIU; C.-J. ZHAO; Y.-X. JIANG; Y.-R. WANG; X.-Y. DAI; W.-N. ZHANG; T. SUN; J.-Q. YU
- Abstract
AIM: The present study was con- ducted to investigate whether LBP had a protective effect on cerebral ischemic reperfusion injury and to determine the possible mechanisms. MATERIALS AND METHODS: Male Kunming (KM) mice were used to make the model cerebral artery occlusion/reperfusion (MCAO/R). The behavioral test was used to measure neurological deficit scores for evaluation of ischemic reperfusion damage of brain. The change of electroencephalograph (EEG) was monitored by Model SMUP-E Bio-electric Signals Processing System. The infarction area of brain was assessed in brain slices with 2% solution of 2,3,5-triphenyl tetrazolium chloride (TTC). Spectrophotometric assay was used to determine the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and lactate dehydrogenase (LDH), contents of malondialdehyde (MDA) and adenosine triphosphate (ATP) of the brain. RESULTS: The results showed that LBP at doses of 20 and 40 mg/kg markedly decreased the neurological deficit scores and the infarction area in MCAO/R mice. At the same time, LBP significantly decreased MDA content, and increased SOD, GSH-Px, CAT, LDH activities in ischemic reperfusion brain. CONCLUSIONS: These suggest that LBP might act as a potential neuroprotective agent against the cerebral reperfusion-induced injury in the brain through reducing lipid peroxides, scavenging free radicals, and improving the energy metabolism.
- Subjects
NEUROPROTECTIVE agents; DRUGS; BRAIN; REPERFUSION; DEGENERATION (Pathology)
- Publication
European Review for Medical & Pharmacological Sciences, 2013, Vol 17, Issue 20, p2760
- ISSN
1128-3602
- Publication type
Article