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- Title
Evidence of intra-familial transmission of Helicobacter pylori by PCR-based RAPD fingerprinting in Bangladesh.
- Authors
Nahar, S.; Kibria, K. M. K.; Hossain, Md. E.; Sultana, J.; Sarker, S. A.; Engstrand, L.; Bardhan, P. K.; Rahman, M.; Endtz, H. P.
- Abstract
Helicobacter pylori is a genetically diverse bacterial species, which has facilitated adaptation to new hosts and persists worldwide. The main objective of this study was to explore intra-familial transmission of H. pylori in Bangladesh. We characterized H. pylori in 35 families including 138 family members using random amplified polymorphic DNA (RAPD) fingerprinting. Forty-six percent of H. pylori isolated from the mother shared a related genotype with strains isolated from their children. Twenty-nine percent of H. pylori isolates of the mother are related to the youngest children. Only 6% of the parents shared related genotype of H. pylori. These findings suggest that mother-to-child transmission occurs in early childhood and is the most probable route of transmission of H. pylori in Bangladesh.
- Subjects
BANGLADESH; HELICOBACTER pylori; BACTERIAL genomes; GENETIC polymorphisms; BACTERIAL transformation; CHILD rearing; HUMAN fingerprints; RAPD technique; BIRTH order
- Publication
European Journal of Clinical Microbiology & Infectious Diseases, 2009, Vol 28, Issue 7, p767
- ISSN
0934-9723
- Publication type
Article
- DOI
10.1007/s10096-008-0699-8