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- Title
Combination Antidepressant Therapy vs Monotherapy-Further Considerations.
- Authors
Wang, Qi; Yao, Liang; Chen, Yaolong
- Abstract
Comment & Response B To the Editor b Henssler et al[1] conducted a systematic review and meta-analysis to investigate the treatment efficacy and tolerability of combining antidepressants vs monotherapy in adult patients with acute depression. Their meta-analysis found that combination therapy was superior to monotherapy in treatment efficacy (primary outcome standardized mean difference [SMD], 0.31; 95% CI, 0.19-0.44), and among the combinations, combining a reuptake inhibitor with an antagonist of presynaptic 2-autoreceptors (RI+ 2) was associated with better outcomes than other combinations (SMD, 0.37; 95% CI, 0.19-0.55). Based on the findings, the authors concluded that combining antidepressants seemed to be more effective than monotherapy and that RI+ 2 appeared to be the most effective combination therapy.
- Subjects
ANTIDEPRESSANTS; COMBINATION drug therapy; TREATMENT effectiveness; MENTAL depression; COMBINED modality therapy
- Publication
JAMA Psychiatry, 2022, Vol 79, Issue 8, p831
- ISSN
2168-622X
- Publication type
journal article
- DOI
10.1001/jamapsychiatry.2022.1391