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- Title
Cutaneous Breast Cancer Metastases Successfully Treated Using an Oxygen Flow Assisted Topical Administration of Methotrexate (OFAMTX).
- Authors
Jouret, Gaëlle; Gonne, Elodie; Quatresooz, Pascale; Reginster, Marie-Annick; Collins, Patrick; Lebas, Eve; Jerusalem, Guy; Nikkels, Arjen F.
- Abstract
Introduction: Cutaneous metastases of breast cancer remain a therapeutic challenge. Oxygen flow-assisted topical administration of methotrexate 5% (OFAMTX, 5% methotrexate in a carrier solution) has recently been proven to be an efficacious alternative treatment for extramammary Paget's disease, which is considered to be an in situ mammary adenocarcinoma of the epidermis. Case Report: A 51-year-old patient with triple negative breast cancer presenting with biopsy-proven skin metastases on the chest agreed to a treatment with OFAMTX5%. The treatment duration was 2 weeks and consisted of twice-weekly sessions with OFAMTX5% applied to an area of skin of approximately 40 cm2. Skin biopsies were performed before and 2 months after procedure. The tolerance to the treatment was excellent, and no pain sensations were experienced. Two months post-procedure the treated area presented a post-inflammatory hyperpigmentation. No residual metastatic lesions were detectable on the control skin biopsy. Six months post-procedure the patient is still in clinical remission. Discussion: OFAMTX5% represents an alternative skin-directed, painless, patient-friendly and efficacious adjuvant treatment for superficial metastatic lesions of breast cancer. Larger series are required to evaluate the potential of OFAMTX5% for the treatment of superficial metastatic lesions of breast cancer.
- Subjects
METASTATIC breast cancer; TRIPLE-negative breast cancer; DISEASE remission; METHOTREXATE; HYPERPIGMENTATION; SKIN biopsy; MOHS surgery; NASAL cannula; TOPICAL drug administration
- Publication
Dermatology & Therapy, 2020, Vol 10, Issue 4, p855
- ISSN
2193-8210
- Publication type
Article
- DOI
10.1007/s13555-020-00393-9