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- Title
Retinoids: Mechanisms of Action in Neuronal Cell Fate Acquisition.
- Authors
Koshy, Aysis Maria; Mendoza-Parra, Marco Antonio
- Abstract
Neuronal differentiation has been shown to be directed by retinoid action during embryo development and has been exploited in various in vitro cell differentiation systems. In this review, we summarize the role of retinoids through the activation of their specific retinoic acid nuclear receptors during embryo development and also in a variety of in vitro strategies for neuronal differentiation, including recent efforts in driving cell specialization towards a range of neuronal subtypes and glial cells. Finally, we highlight the role of retinoic acid in recent protocols recapitulating nervous tissue complexity (cerebral organoids). Overall, we expect that this effort might pave the way for exploring the usage of specific synthetic retinoids for directing complex nervous tissue differentiation.
- Subjects
RETINOID X receptors; RETINOIC acid receptors; NEURONAL differentiation; RETINOIDS; NERVE tissue; TISSUE differentiation; CELL differentiation
- Publication
Life (2075-1729), 2023, Vol 13, Issue 12, p2279
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life13122279