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- Title
Budd-Chiari-like pathology in dolphins.
- Authors
Fernandez, Antonio; Jepson, Paul D.; Diaz-Delgado, Josue; de Quiros, Yara Bernaldo; Sierra, Eva; Mompeo, Blanca; Vela, Ana Isabel; Di Guardo, Giovanni; Suarez-Santana, Cristian; de los Monteros, Antonio Espinosa; Herraez, Pedro; Andrada, Marisa; Caballero, Maria Jose; Rivero, Miguel; Consoli, Francesco; Castro-Alonso, Ayoze; Quesada-Canales, Oscar; Arbelo, Manuel
- Abstract
Nearly two decades ago, pathologic examination results suggested that acoustic factors, such as mid-frequency active naval military sonar (MFAS) could be the cause of acute decompression-like sickness in stranded beaked whales. Acute systemic gas embolism in these whales was reported together with enigmatic cystic liver lesions (CLL), characterized by intrahepatic encapsulated gas-filled cysts, tentatively interpreted as "gas-bubble" lesions in various other cetacean species. Here we provide a pathologic reinterpretation of CLL in odontocetes. Among 1,200 cetaceans necropsied, CLL were only observed in four striped dolphins (Stenella coeruleoalba), with a low prevalence (2%, N = 179). Together, our data strongly suggest that CLL are the result of the combination of a pre-existing or concomitant hepatic vascular disorder superimposed and exacerbated by gas bubbles, and clearly differ from acute systemic gas embolism in stranded beaked whales that is linked to MFAS. Budd-Chiari-like syndrome in dolphins is hypothesized based on the present pathologic findings. Nonetheless, further researched is warranted to determine precise etiopathogenesis(es) and contributing factors for CLL in cetaceans.
- Subjects
STRIPED dolphin; GAS embolism; BEAKED whales; DOLPHINS; TOOTHED whales; CETACEA; PATHOLOGY; CHRONIC lymphocytic leukemia
- Publication
Scientific Reports, 2022, Vol 12, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-022-16947-0