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- Title
Does isotretinoin have an effect on glucose metabolism, insulin growth factor-1 and insulin-like growth factor-3 binding protein?
- Authors
Doğan, Esra Inan
- Abstract
Introduction: Isotretinoin is the only effective agent at all stages of acne vulgaris, but its effects on certain systems remain unkown. Objective: To evaluate the effects of isotretinoin and other acne treatments on insulin growth factor-1 (IGF-1), insulin-like growth factor-3 binding protein (IGFBP-3), insulin, C-peptide, glucose and glycated hemoglobin A1c (HbA1c), and HOMA-IR. Material and methods: Eighty one patients with acne vulgaris were divided into two groups: the first group was treated with isotretinoin and the second group treated with systemic minocycline and topical benzoyl peroxide (in combined treatment). IGF-1, IGFBP3, insulin, HOMA-IR, C-peptide, glucose and HbA1c serum levels were assessed in two groups. Results: IGFBP-3 levels were significantly increased in patients receiving isotretinoin treatment for 3 months. When isotretinoin and combined treatment groups were compared, a significant rise in the IGF-1 level was found in the combined treatment group. Unlike the literature, our results showed that the commonly used acne treatments did not change the serum levels of IGF-1, insulin, C-peptide, glucose and HbA1c significantly. Conclusions: Consequently, we showed that isotretinoin did not impair glucose metabolism in patients who were previously not obese or insulin resistant. Since IGF-1, IGFBP-3 parameters have effects on cell growth and proliferation, we suggest that they play an effective role in acne pathogenesis and treatment mechanism.
- Subjects
ISOTRETINOIN; GLUCOSE metabolism; SOMATOMEDIN; BENZOYL peroxide; MINOCYCLINE
- Publication
Dermatology Review / Przeglad Dermatologiczny, 2021, Vol 108, Issue 5, p361
- ISSN
0033-2526
- Publication type
Article
- DOI
10.5114/dr.2021.113154