We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease.
- Authors
de Hemptinne, Coralie; Swann, Nicole C; Ostrem, Jill L; Ryapolova-Webb, Elena S; San Luciano, Marta; Galifianakis, Nicholas B; Starr, Philip A
- Abstract
Deep brain stimulation (DBS) is increasingly applied for the treatment of brain disorders, but its mechanism of action remains unknown. Here we evaluate the effect of basal ganglia DBS on cortical function using invasive cortical recordings in Parkinson's disease (PD) patients undergoing DBS implantation surgery. In the primary motor cortex of PD patients, neuronal population spiking is excessively synchronized to the phase of network oscillations. This manifests in brain surface recordings as exaggerated coupling between the phase of the beta rhythm and the amplitude of broadband activity. We show that acute therapeutic DBS reversibly reduces phase-amplitude interactions over a similar time course as that of the reduction in parkinsonian motor signs. We propose that DBS of the basal ganglia improves cortical function by alleviating excessive beta phase locking of motor cortex neurons.
- Subjects
BRAIN stimulation; BRAIN diseases; PARKINSON'S disease; OSCILLATIONS; MOTOR ability; MOTOR cortex
- Publication
Nature Neuroscience, 2015, Vol 18, Issue 5, p779
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.3997