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- Title
Thyroid Hormone Regulation of Heart Metabolism.
- Authors
Michael A. Portman
- Abstract
Thyroid hormone regulates cardiac metabolism through multiple mechanisms. Traditionally, most cardiac metabolic studies have focused on presumed transcriptional actions by defining thyroid hormoneinduced changes in mRNA or protein levels. Recent studies have established metabolic pathways in heart that rapidly respond to thyroid hormone. Functions have also been implicated for thyroid hormone receptors, which are separate from their transcriptional actions. Finally, thyroid through ligand binding may play a direct role in transactivation of mitochondrial DNA. This review will explore these newly identified modes of thyroid action on metabolism in heart.
- Subjects
THYROID hormones; REGULATION of heart metabolism; MITOCHONDRIAL DNA; NUCLEIC acids
- Publication
Thyroid, 2008, Vol 18, Issue 2, p217
- ISSN
1050-7256
- Publication type
Article
- DOI
10.1089/thy.2007.0257