We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
EFFECT OF ALPHA TOCOPHEROL ON CHRONIC STRESS INDUCED DERANGEMENTS IN NEUROPEPTIDE Y ON SPRAGUE DAWLEY RATS.
- Authors
Zainab, Saadia; Khan, Umar Ali; Lodhi, Ghulam Mustafa; Asad, Munazza
- Abstract
Objective: To determine the chronic stress induced decline in plasma Neuropeptide Y (NPY) level and protective effects of Alpha Tocopherol (AT) on maintenance of Neuropeptide Y level. Study Design: Quasi-experimental study. Place and Duration of Study: The study settings were Al-Nafees Medical College and animal center of National Institute of Health Islamabad (NIH). Duration of research was one year from May 2015 to May 2016. Methodology: After taking approval of institutional review board 45 male Sprague Dawley rats with inclusion criteria were chosen and allocated to three groups comprised of n=15. Group I was control, group II restraint stress and group III (restraint stress with supplementation of alpha-tocopherol). After 28 days of restraining stress induction plasma Neuropeptide Y level was determined by sandwich Enzyme Linked Immunosorbent Assay (ELISA). Results: There was a statistically significant decline (p<0.05) in plasma Neuropeptide Y levels in restraint group as compared to control group and with alpha-tocopherol supplementation group. Conclusion: Chronic restraint stress induction led to decline in Neuropeptide Y levels and alpha-tocopherol prevented fall in Neuropeptide Y levels.
- Subjects
NEUROPEPTIDE Y; SPRAGUE Dawley rats; INSTITUTIONAL review boards; VITAMIN E; IMMOBILIZATION stress
- Publication
Pakistan Armed Forces Medical Journal, 2020, Vol 70, Issue 3, p776
- ISSN
0030-9648
- Publication type
Article