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- Title
مؤثر بر سیستم ایمنی بیماران دیابتی مبتلا به عفونت انگلی IL-و 6 TGF-β بررسی سطح سرمی سایتوکاینهاي توکسوپلاسما: یک گزارش کوتاه
- Authors
Dabirzadeh, Mansour; Beigi, Roghayeh Hossein; Poursamimi, Javad; Yaqoubi, Ladan Arab
- Abstract
Background and Objectives: Cytokines play an essential role in regulating the interaction of immune cells in diabetes and infections such as toxoplasmosis. This study was conducted to investigate the serum levels of Interleukin-6 (IL-6) and Transforming Growth Factor-Beta (TGF-P) in diabetic patients with toxoplasmosis. Materials and Methods: This study was conducted in Zabol City on patients with type I and type II diabetes, both with and without toxoplasmosis. The serum levels of target cytokines were measured using the ELISA method. Data analysis was performed using oneway ANOVA, and chi-square test was utilized to examine demographic indices. Results: A significant increase in TGF-β levels was observed in the group with type II diabetes and toxoplasmosis. Additionally, a slight rise in serum IL-6 levels was noted in the group with type I diabetes. However, the level of TGF-β was decreased in this group. Conclusions: The present study revealed that an increase in TGF-β and a decrease in IL-6 in patients with type II diabetes and toxoplasmosis may indicate a reduction in inflammation within this specific group.
- Subjects
TYPE 2 diabetes; TYPE 1 diabetes; TOXOPLASMOSIS; PEOPLE with diabetes; CHI-squared test
- Publication
Journal of Rafsanjan University of Medical Sciences, 2024, Vol 23, Issue 3, p164
- ISSN
1735-3165
- Publication type
Article
- DOI
10.61186/jrums.23.3.164