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- Title
Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone.
- Authors
Ruiz-Rubio, Leire; Alonso, María Luz; Pérez-Álvarez, Leyre; Alonso, Rosa Maria; Vilas, Jose Luis; Khutoryanskiy, Vitaliy V.
- Abstract
Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols® (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro.
- Subjects
POLYETHYLENE; HYDROCORTISONE; EXCIPIENTS; DRUG delivery systems; MEDICAL polymers
- Publication
Polymers (20734360), 2018, Vol 10, Issue 2, p175
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym10020175