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- Title
Reação de Mannich: Metodologia Clássica na Formação de Ligação Carbono-Carbono.
- Authors
Allochio Filho, João F.; Fiorot, Rodolfo G.; Delarmelina, Maicon; Lacerda Jr., Valdemar; dos Santos, Reginaldo B.; Greco, Sandro J.
- Abstract
The Mannich reaction is a classical method for the preparation of β-aminoketones and aldeydes (Mannich bases) and, as such, is one the most important reaction in organic chemistry. The resulting Mannich bases are of particular interest due to their biological activity, use as synthetic building blocks, and precursors of valuable pharmaceuticals products. In this context, various elegant stereoselective α-aminoalkylations have been developed.
- Subjects
MANNICH reaction; AMINO ketones; ALDEHYDE synthesis; ORGANIC chemistry; SYNTHETIC biology
- Publication
Orbital: The Electronic Journal of Chemistry, 2013, Vol 5, Issue 2, p96
- ISSN
1984-6428
- Publication type
Article