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- Title
An eight-step gram-scale synthesis of (−)-jiadifenolide.
- Authors
Lu, Hai-Hua; Martinez, Michael D.; Shenvi, Ryan A.
- Abstract
Development of a biologically active secondary metabolite into a useful medicine requires continuous access to meaningful quantities of material. Although any chemical synthesis is broadly useful for its versatility, identification of a synthesis route that can be economically scaled represents a greater challenge. Here we report a concise synthesis of the neurotrophic trace metabolite (−)-jiadifenolide and its production on a gram-scale. The brevity of the route and the structural similarity of a key intermediate to many potent Illicium terpenes make chemical synthesis the unquestionable method for accessing and modifying these potential therapeutics.
- Subjects
CHEMICAL synthesis; METABOLITES; NEUROTROPHINS; INTERMEDIATES (Chemistry); ILLICIUM; THERAPEUTICS
- Publication
Nature Chemistry, 2015, Vol 7, Issue 7, p604
- ISSN
1755-4330
- Publication type
Article
- DOI
10.1038/nchem.2283