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- Title
Palladium‐Catalzyed Atroposelective 16‐Membered Macrocyclization: Total Synthesis of Isoplagiochin D<sup>†</sup>.
- Authors
Xi, Junwei; Gu, Zhenhua
- Abstract
Summary of main observation and conclusion: Isoplagiochin D is a ring‐strained macrocyclic bisbibenzylis, which showed stable axial chirality in one biaryl structure, and semistable axial chirality in the other biaryl moiety. We reported here an unprecedented example for the catalytically asymmetric synthesis of ring‐strained atropisomers via Pd‐catalyzed macrocyclization between benzyl halides and carbenes. This newly developed Pd‐catalyzed asymmetric macrocyclization protocol enabled us a quick synthesis of isoplagiochin D in a highly enantioselective manner.
- Subjects
BENZYL halides; CHIRALITY; ATROPISOMERS; MOIETIES (Chemistry); ASYMMETRIC synthesis
- Publication
Chinese Journal of Chemistry, 2020, Vol 38, Issue 10, p1081
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202000051