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- Title
Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections.
- Authors
Achterman, Rebecca Rashid; White, Theodore C.
- Abstract
Dermatophytes are prevalent causes of cutaneous mycoses and, unlike many other fungal pathogens, are able to cause disease in immunocompetent individuals. They infect keratinized tissue such as skin, hair, and nails, resulting in tinea infections, including ringworm. Little is known about the molecular mechanisms that underlie the ability of these organisms to establish and maintain infection. The recent availability of genome sequence information and improved genetic manipulation have enabled researchers to begin to identify and study the role of virulence factors of dermatophytes. This paper will summarize our current understanding of dermatophyte virulence factors and discuss future directions for identifying and testing virulence factors.
- Subjects
DERMATOPHYTES; MICROBIAL virulence; SKIN diseases; DERMATOMYCOSES; IMMUNOCOMPETENT cells; KERATINIZATION; MOLECULAR biology; NUCLEOTIDE sequence
- Publication
International Journal of Microbiology, 2012, p1
- ISSN
1687-918X
- Publication type
Article
- DOI
10.1155/2012/358305