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- Title
Blood Purification Techniques, Inflammatory Mediators and Mortality in COVID-19 Patients.
- Authors
Hashemian, Seyed Mohammadreza; Shafigh, Navid; Afzal, Golnaz; Jamaati, Hamidreza; Mortaz, Esmaeil; Tabarsi, Payam; Marjani, Majid; Malekmohammad, Majid; Dastan, Farzaneh; Mortazavi, Seyed Mehdi; Sadr, Makan; Idani, Esmaeil; Khoundabi, Batoul; Mohamadnia, Abdolreza; Abedini, Atefeh; Kiani, Arda; Moniri, Afshin; Nadji, Seyed Alireza; Yassari, Fatemeh; Dezfuli, Mojtaba Mokhber
- Abstract
Background: Inflammatory mediators are an important component in the pathophysiology of the coronavirus disease 2019 (COVID-19). This study aimed to assess the effects of reducing inflammatory mediators using hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on the mortality of patients with COVID-19. Materials and Methods: Twelve patients with confirmed diagnosis of COVID-19 were included. All patients had acute respiratory distress syndrome (ARDS). Patients were divided into three groups, namely, HP, CRRT and HP+CRRT. The primary outcome was mortality and the secondary outcomes were oxygenation and reduction in inflammatory mediators at the end of the study. Results: Patients were not different at baseline in demographics, inflammatory cytokine levels, and the level of acute phase reactants. Half of the patients (3 out of 6) in the HP+CRRT group survived along with the survival of one patient (1 out of 2) in the HP group. All four patients in the CRRT group died. Serum creatinine (SCr), Interleukin-1 (IL1), Interleukin-6 (IL6), Interleukin-8 (IL8), partial pressure of oxygen (PaO2), O2 saturation (O2 sat), and hemodynamic parameters improved over time in HP+CRRT and CRRT groups, but no significant difference was observed in the HP group (All Ps > 0.05). Conclusion: Combined HP and CRRT demonstrated the best result in terms of mortality, reduction of inflammatory mediators and oxygenation. Further investigations are needed to explore the role of HP+CRRT in COVID-19 patients.
- Subjects
INFLAMMATORY mediators; COVID-19; ACUTE phase proteins; ADULT respiratory distress syndrome; RENAL replacement therapy
- Publication
Tanaffos, 2020, Vol 19, Issue 4, p291
- ISSN
1735-0344
- Publication type
Article