We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Myeloperoxidase and associated lung disease: Review of the latest developments.
- Authors
Hu, Hannah; Keat, Karuna
- Abstract
Myeloperoxidase (MPO) anti‐neutrophil cytoplasmic antibodies (ANCA) are often detected in association with a variety of lung pathologies, the most common being interstitial lung disease (ILD). A growing cohort of patients are being diagnosed with MPO‐ANCA in the context of ILD without ANCA‐associated vasculitis. Clinically and radiologically, there is little to differentiate this cohort from MPO‐ANCA‐negative ILD patients; however, the pathophysiology is likely different and different treatments are likely required. We present here a brief summary of the proposed pathophysiology of MPO‐ANCA‐positive ILD, and a more detailed review of the latest evidence on management, including monitoring for development of ANCA‐associated vasculitis, immunosuppression, anti‐fibrotics, and novel agents that have yet to be trialled in human experiments.
- Subjects
LUNG diseases; DISEASE complications; MYELOPEROXIDASE; ANTINEUTROPHIL cytoplasmic antibodies; PATHOLOGICAL physiology; INTERSTITIAL lung diseases
- Publication
International Journal of Rheumatic Diseases, 2021, Vol 24, Issue 12, p1460
- ISSN
1756-1841
- Publication type
Article
- DOI
10.1111/1756-185X.14213