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- Title
Combination antiviral therapy for influenza: predictions from modeling of human infections.
- Authors
Perelson AS; Rong L; Hayden FG; Perelson, Alan S; Rong, Libin; Hayden, Frederick G
- Abstract
Emergence of resistance is a major concern in influenza antiviral treatment and prophylaxis. Combination antiviral therapy might overcome this problem. Here, we estimate that all possible single mutants and a sizeable fraction of double mutants are generated during an uncomplicated influenza infection. While most of them may sustain a fitness cost, some variants may confer drug resistance and be selected during therapy. We argue that a triple combination regimen would markedly reduce the risk of antiviral resistance emergence in seasonal and pandemic influenza viruses, especially in seriously ill or immunocompromised hosts.
- Subjects
ANTIVIRAL agents; CHEMOPREVENTION; COMBINATION drug therapy; DRUG resistance in microorganisms; GENETICS; INFLUENZA; MATHEMATICAL models; GENETIC mutation; ORTHOMYXOVIRUSES; RESEARCH funding; THEORY
- Publication
Journal of Infectious Diseases, 2012, Vol 205, Issue 11, p1642
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jis265