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- Title
MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death
- Authors
Kim, Jae-Hong; Sim, Se-Hoon; Ha, Hye-Jeong; Ko, Jeong-Jae; Lee, Kangseok; Bae, Jeehyeon
- Abstract
Abstract: Myeloid cell leukemia-1 (MCL-1L) is a pro-survival member of the BCL-2 family that promotes cell survival. In this study, we identify a new splicing variant of human MCL-1 that encodes MCL-1ES (extra short). Sequence analysis indicates that this variant results from splicing within the first coding exon of MCL-1 at a non-canonical GC–AG donor–acceptor pair. The deduced sequence of MCL-1ES encodes a protein of 197 amino acids, and the PEST (proline, glutamic acid, serine, and threonine) motifs present in MCL-1L are absent. MCL-1ES interacts with MCL-1L and induces mitochondrial cell death, suggesting that alternative splicing of MCL-1 may control the fate of cells. Structured summary: MINT-7255705, MINT-7255718, MINT-7255731, MINT-7255743:MCL1-ES (uniprotkb:Q07820-2) physically interacts (MI:0914) with MCL1-1L (uniprotkb:Q07820-1) by anti tag coimmunoprecipitation (MI:0007) MINT-7255771:MCL1-ES (uniprotkb:Q07820-2) physically interacts (MI:0914) with Beta actin (uniprotkb:P60709) by anti tag coimmunoprecipitation (MI:0007) MINT-7255781:MCL1-ES (uniprotkb:Q07820-2) physically interacts (MI:0914) with GAPDH (uniprotkb:P04406) by anti tag coimmunoprecipitation (MI:0007) MINT-7255756:MCL1-ES (uniprotkb:Q07820-2) physically interacts (MI:0914) with COX IV (uniprotkb:P13073) by anti tag coimmunoprecipitation (MI:0007)
- Subjects
MYELOID leukemia; MITOCHONDRIA; CELL death; AMINO acids; GENETIC regulation; GENETIC code; GLUTAMIC acid; APOPTOSIS
- Publication
FEBS Letters, 2009, Vol 583, Issue 17, p2758
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.08.006